β-LacFamPred: HMM based prediction and annotation tool for β-lactamase families
About β-lactamase
Beta-lactamases are enzymes produced by bacteria that provide multi-resistance to β-lactam antibiotics such as penicillins, cephalosporins, cephamycins, and carbapenems (ertapenem), although carbapenems are relatively resistant to beta-lactamase.
Welcome to β-LacFamPred
β-LacFamPred used for prediction and annotation of Ambler's class, subclass and 96 family of beta-lactamase (BLs) into proteins/genes sequences with complete annotation. This method was based on profile Hidden Markov Models (pHMM) which is a probalistic method it includes evolutionary information (MSA) of each family also it facilitated with detailed annotation. Perfromance of each pHMM is evaluated using leave-one-out cross-validation (LOOCV) during which 94 HMM showed 100% accuracy.
Here we describe a novel profile HMM based in-silico tool, β-LacFamPred, to predict β-lactamase familes using protein/gene sequences. The β-lacFamPred standalone software and web-server are freely available for academic use under GNU GPL.
β-LacFamPred Predicts
β-LacFamPred Facilitate
Click hereFind the family of Beta-lactamase family of your proteins/gene sequence.
Click hereGet the and Sequences, MSAs & HMM models of all families.
Click hereHow to search and analyze in the β-LacFamPred?