Family: GES
Class: A
Number of Variants: 21
Number of Proteins: 32
Number of Structures: 6
Taxonomic Lineage: Bacteria > Proteobacteria > Gammaproteobacteria

Alignment Variability Plot Phylogenetic Tree Mutational Profile   Fingerprint     Sequences  

<
Variants Organism Uniprot ID PDB ID Hydrolytic profile Embl ID Genbank ID
Ges-1 Klebsiella pneumoniae Q9KJY7 2QPN NA AY219651 AY219651.1
Pseudomonas aeruginosa Q7BEB3 NA NA GU831563 GU831563.1
Escherichia coli D3U0R3 NA NA FJ696404 FJ696404.1
Ges-2 Pseudomonas aeruginosa Q93F76 3NI9 3NIA Imipenem AF326355 AF326355.1
Ges-3 Klebsiella pneumoniae Q767E8 NA Ceftazidime AB113580 AB113580.1
Escherichia coli Q6RSM8 NA NA AY494717 AY494717.1
Ges-4 Klebsiella pneumoniae Q764B7 NA Cephamycin AB116723 AB116723.1
Klebsiella pneumoniae Q6RSM7 NA NA AY494718 HQ170511.1
Ges-5 Pseudomonas aeruginosa A0EL75 NA NA GQ337064 GQ337064.1
Klebsiella pneumoniae C5MQW2 NA NA GQ139471 GQ139471.1
Uncultured Bacterium H2E8M0 NA Carbapenem JN849689 JN849689.1
Enterobacter cloacae B9TSF9 NA NA EU266532 EU266532.1
Klebsiella pneumoniae Q09HD0 NA NA DQ902344 DQ902344
Ges-7 Aeromonas media F1BYN3 NA NA HQ170511 HQ170511.1
Aeromonas media E9L0D0 NA NA HQ170511 HQ170511.1
Ges-9 Pseudomonas aeruginosa Q49HG5 NA NA AY920928 AY920928.1
Ges-10 Uncultured bacterium C6GC02 NA NA FJ820124 FJ820124.1
Ges-11 Acinetobacter baumanni C5HUY1 3V3R NA KC469284 KC469284.1
Klebsiella oxytoca H6U580 NA NA JN596279 JN596279.1
Acinetobacter baumanni I3VFR3 NA NA JQ764759 JQ764759.1
Ges-12 Acinetobacter baumannii C8ZLL4 NA NA HM622145 HM622145.1
Ges-13 Pseudomonas aeruginosa D1MIX9 NA NA GU169702 GU169702.1
Ges-14 Acinetobacter baumannii D3X610 3TSG NA GU207844 GU207844.1
Ges-15 Pseudomonas aeruginosa D2KFE7 NA NA GU208678 GU208678.1
Ges-16 Serratia marcescens D9IR25 NA NA HM173356 HM173356.1
Ges-17 Escherichia coli F2YBS7 NA NA HQ874631 HQ874631.1
Ges-18 Pseudomonas aeruginosa H2ERK4 3V3S Carbapenem JQ028729 JQ028729.1
Ges-19 Escherichia coli H6U587 NA NA JN596280 JN596280.1
Ges-20 Escherichia coli H6U588 NA NA JN596280 JN596280.1
Ges-21 Uncultured bacterium I3VLI2 NA NA JQ772478 JQ772478.1
Ges-22 Acinetobacter baumannii K0GF29 NA NA JX023441 JX023441.1
Ges-23 Pseudomonas aeruginosa S5YYN5 NA NA KF179354 KF179354.1
Ges-24 Enterobacter cloacae W8VY40 NA NA AB914515 AB914515.1
References
  • Poirel L, Le Thomas I, Naas T, Karim A, Nordmann P. Biochemical sequence analyses of GES-1, a novel class A extended-spectrum beta-lactamase, and the class 1 integron In52 from Klebsiella pneumoniae. Antimicrob Agents Chemother. 2000 Mar;44(3):622-32.PubMed PMID: 10681329
  • Smith CA, Caccamo M, Kantardjieff KA, Vakulenko S. Structure of GES-1 at atomic resolution: insights into the evolution of carbapenamase activity in the class A extended-spectrum beta-lactamases. Acta Crystallogr D Biol Crystallogr.2007 Sep;63(Pt 9):982-92. Epub 2007 Aug 17.PubMed PMID: 17704567.
  • Correia M, Boavida F, Grosso F, Salgado MJ, Lito LM, Cristino JM, Mendo S,Duarte A. Molecular characterization of a new class 3 integron in Klebsiella pneumoniae. Antimicrob Agents Chemother. 2003 Sep;47(9):2838-43.PubMed PMID:12936982
  • Poirel L, Carattoli A, Bernabeu S, Bruderer T, Frei R, Nordmann P. A novel IncQ plasmid type harbouring a class 3 integron from Escherichia coli. J Antimicrob Chemother. 2010 Aug;65(8):1594-8. doi:10.1093/jac/dkq166. Epub 2010Jun 5. PubMed PMID: 20525990
  • Dubois V, Poirel L, Marie C, Arpin C, Nordmann P, Quentin C. Molecular characterization of a novel class 1 integron containing bla(GES-1) and a fused product of aac3-Ib/aac6'-Ib' gene cassettes in Pseudomonas aeruginosa. AntimicrobAgents Chemother. 2002 Mar;46(3):638-45.PubMed PMID:11850242
  • da Fonseca EL, Vieira VV, Cipriano R, Vicente AC. Emergence of blaGES-5 inclinical colistin-only-sensitive (COS) Pseudomonas aeruginosa strain in Brazil. JAntimicrob Chemother. 2007 Mar;59(3):576-7. Epub 2007 Feb 6.PubMed PMID:17284538
  • Papagiannitsis CC, Tzouvelekis LS, Miriagou V. Relative strengths of the class1 integron promoter hybrid 2 and the combinations of strong and hybrid 1 with an active p2 promoter. Antimicrob Agents Chemother. 2009 Jan;53(1):277-80. doi:10.1128/AAC.00912-08. Epub 2008 Nov 10.PubMed PMID: 19001114
  • Viedma E, Juan C, Acosta J, Zamorano L, Otero JR, Sanz F, Chaves F, Oliver A. Nosocomial spread of colistin-only-sensitive sequence type 235 Pseudomonas aeruginosa isolates producing the extended-spectrum beta-lactamases GES-1 andGES-5 in Spain. Antimicrob Agents Chemother. 2009 Nov;53(11):4930-3. doi:10.1128/AAC.00900-09. Epub 2009 Sep 8.PubMed PMID: 19738007
    •
  • Poirel L, Weldhagen GF, Naas T, De Champs C, Dove MG, Nordmann P. GES-2, a class A beta-lactamase from Pseudomonas aeruginosa with increased hydrolysis of imipenem. Antimicrob Agents Chemother. 2001 Sep;45(9):2598-603.PubMed PMID:11502535
  • Vourli S, Giakkoupi P, Miriagou V, Tzelepi E, Vatopoulos AC, Tzouvelekis LS.Novel GES/IBC extended-spectrum beta-lactamase variants with carbapenemase activity in clinical enterobacteria. FEMS Microbiol Lett. 2004 May 15;234(2):209-13. PubMed PMID: 15135524
  • Wachino J, Doi Y, Yamane K, Shibata N, Yagi T, Kubota T, Ito H, Arakawa Y.Nosocomial spread of ceftazidime-resistant Klebsiella pneumoniae strains producing a novel class a beta-lactamase, GES-3, in a neonatal intensive care unit in Japan. Antimicrob Agents Chemother. 2004 Jun;48(6):1960-7.PubMed PMID:15155185
  • Wachino J, Doi Y, Yamane K, Shibata N, Yagi T, Kubota T, Arakawa Y. Molecular characterization of a cephamycin-hydrolyzing and inhibitor-resistant class A beta-lactamase, GES-4, possessing a single G170S substitution in the omega-loop. Antimicrob Agents Chemother. 2004 Aug;48(8):2905-10. PubMed PMID: 15273099
  • Vourli S, Giakkoupi P, Miriagou V, Tzelepi E, Vatopoulos AC, Tzouvelekis LS.Novel GES/IBC extended-spectrum beta-lactamase variants with carbapenemase activity in clinical enterobacteria. FEMS Microbiol Lett. 2004 May 15;234(2):209-13. PubMed PMID: 15135524
  • Girlich D, Poirel L, Szczepanowski R, Schlüter A, Nordmann P.Carbapenem-hydrolyzing GES-5-encoding gene on different plasmid types recoveredfrom a bacterial community in a sewage treatment plant. Appl Environ Microbiol.2012 Feb;78(4):1292-5. doi: 10.1128/AEM.06841-11. Epub 2011 Dec 9. PubMed PMID:22156421
  • Labuschagne Cde J, Weldhagen GF, Ehlers MM, Dove MG. Emergence of class 1 integron-associated GES-5 and GES-5-like extended-spectrum beta-lactamases in clinical isolates of Pseudomonas aeruginosa in South Africa. Int J AntimicrobAgents. 2008 Jun;31(6):527-30. doi: 10.1016/j.ijantimicag.2008.01.020. Epub 2008 Apr 23.PubMed PMID: 18436436
  • da Fonseca EL, Vieira VV, Cipriano R, Vicente AC. Emergence of blaGES-5 in clinical colistin-only-sensitive (COS) Pseudomonas aeruginosa strain in Brazil. J Antimicrob Chemother. 2007 Mar;59(3):576-7. Epub 2007 Feb 6.PubMed PMID:17284538.
  • Viedma E, Juan C, Acosta J, Zamorano L, Otero JR, Sanz F, Chaves F, Oliver A. Nosocomial spread of colistin-only-sensitive sequence type 235 Pseudomonas aeruginosa isolates producing the extended-spectrum beta-lactamases GES-1 and GES-5 in Spain. Antimicrob Agents Chemother. 2009 Nov;53(11):4930-3. doi:10.1128/AAC.00900-09. Epub 2009 Sep 8. PubMed PMID: 19738007
  • Martinez E, Marquez C, Ingold A, Merlino J, Djordjevic SP, Stokes HW, Chowdhury PR. Diverse mobilized class 1 integrons are common in the chromosomes of pathogenic Pseudomonas aeruginosa clinical isolates. Antimicrob Agents Chemother. 2012 Apr;56(4):2169-72. doi:10.1128/AAC.06048-11. Epub 2012 Jan 23.PubMed PMID: 22271862
  • Poirel L, Carrër A, Pitout JD, Nordmann P. Integron mobilization unit as asource of mobility of antibiotic resistance genes. Antimicrob Agents Chemother.2009 Jun;53(6):2492-8. doi: 10.1128/AAC.00033-09. Epub 2009 Mar 30.PubMed PMID:19332679
  • Girlich D, Poirel L, Nordmann P. Diversity of clavulanic acid-inhibited extended-spectrum β-lactamases in Aeromonas spp. from the Seine River, Paris,France. Antimicrob Agents Chemother. 2011 Mar;55(3):1256-61. doi:10.1128/AAC.00921-10. Epub 2010 Dec 13.PubMed PMID: 21149627
  • Moura A, Pereira C, Henriques I, Correia A. Novel gene cassettes and integronsin antibiotic-resistant bacteria isolated from urban wastewaters. Res Microbiol.2012 Feb;163(2):92-100. doi: 10.1016/j.resmic.2011.10.010. Epub 2011 Nov 16.PubMed PMID: 22127350
  • Gillings MR, Holley MP, Stokes HW. Evidence for dynamic exchange of qac genecassettes between class 1 integrons and other integrons in freshwater biofilms.FEMS Microbiol Lett. 2009 Jun;296(2):282-8. doi:10.1111/j.1574-6968.2009.01646.x. Epub 2009 May 8.PubMed PMID: 19459951
  • Barrios H, Garza-Ramos U, Ochoa-Sanchez LE, Reyna-Flores F, Rojas-Moreno T,Morfin-Otero R, Rodriguez-Noriega E, Garza-Gonzalez E, Gonzalez G, Volkow P,Cornejo-Juarez P; Red-MEReBa Study Group, Silva-Sanchez J. A plasmid-encodedclass 1 integron contains GES-type extended-spectrum β-lactamases in Enterobacteriaceae clinical isolates in Mexico. Antimicrob Agents Chemother. 2012Jul;56(7):4032-4. doi: 10.1128/AAC.05980-11. Epub 2012 Apr 23. PubMed PMID:22526300
  • Moubareck C, Brémont S, Conroy MC, Courvalin P, Lambert T. GES-11, a novel integron-associated GES variant in Acinetobacter baumannii. Antimicrob Agents Chemother. 2009 Aug;53(8):3579-81. doi: 10.1128/AAC.00072-09. Epub 2009 May 18.PubMed PMID: 19451292
  • Bogaerts P, Naas T, El Garch F, Cuzon G, Deplano A, Delaire T, Huang TD,Lissoir B, Nordmann P, Glupczynski Y. GES extended-spectrum β-lactamases in Acinetobacter baumannii isolates in Belgium. Antimicrob Agents Chemother. 2010Nov;54(11):4872-8. doi: 10.1128/AAC.00871-10. Epub 2010 Aug 30. PubMed PMID:20805394
    •
  • Bonnin RA, Nordmann P, Potron A, Lecuyer H, Zahar JR, Poirel L.Carbapenem-hydrolyzing GES-type extended-spectrum beta-lactamase in Acinetobacterbaumannii. Antimicrob Agents Chemother. 2011 Jan;55(1):349-54. doi:10.1128/AAC.00773-10. Epub 2010 Oct 18. PubMed PMID: 20956589
  • Delbrück H, Bogaerts P, Kupper MB, Rezende de Castro R, Bennink S, GlupczynskiY, Galleni M, Hoffmann KM, Bebrone C. Kinetic and crystallographic studies of extended-spectrum GES-11, GES-12, and GES-14 β-lactamases. Antimicrob AgentsChemother. 2012 Nov;56(11):5618-25. doi: 10.1128/AAC.01272-12. Epub 2012 Aug 20.PubMed PMID: 22908160
  • Bogaerts P, Naas T, El Garch F, Cuzon G, Deplano A, Delaire T, Huang TD,Lissoir B, Nordmann P, Glupczynski Y. GES extended-spectrum β-lactamases in Acinetobacter baumannii isolates in Belgium. Antimicrob Agents Chemother. 2010Nov;54(11):4872-8. doi: 10.1128/AAC.00871-10. Epub 2010 Aug 30. PubMed PMID:20805394
  • Kotsakis SD, Papagiannitsis CC, Tzelepi E, Legakis NJ, Miriagou V, TzouvelekisLS. GES-13, a beta-lactamase variant possessing Lys-104 and Asn-170 in Pseudomonas aeruginosa. Antimicrob Agents Chemother. 2010 Mar;54(3):1331-3. doi:10.1128/AAC.01561-09. Epub 2010 Jan 11. PubMed PMID: 20065056
  • Bebrone C, Bogaerts P, Delbrück H, Bennink S, Kupper MB, Rezende de Castro R, Glupczynski Y, Hoffmann KM. GES-18, a new carbapenem-hydrolyzing GES-Typeβ-lactamase from Pseudomonas aeruginosa that contains Ile80 and Ser170 residues. Antimicrob Agents Chemother. 2013 Jan;57(1):396-401. doi: 10.1128/AAC.01784-12.Epub 2012 Oct 31.PubMed PMID: 23114760