Ambler Classification is the skeleton of CBMAR. Ambler classification grouped all β-Lactamases into four classes (A-D) based upon their amino acid sequences. Class B enzymes are metallo-β-lactamases, while enzymes of classes A, C and D are serine transferases. Each class is further divided into families on the basis of statistically significant similarities in amino acid sequences, as well as there characteristics like origin of name, hydrolyzing properties toward β-lactam antibiotics, geographical diversity etc. Each family is hyperlinked with a summery page containing different variants, sequence information and their source. For more information see Help page.
