Family: KPC
Class: A
Number of Variants: 17
Number of Proteins: 97
Number of Structures: 7
Taxonomic Lineage: Bacteria > Proteobacteria > Gammaproteobacteria

  Alignment     Variability Plot     Phylogenetic Tree     Mutational Profile     Fingerprint     Sequences  

Variants Organism Uniprot ID PDB ID Hydrolytic profile Embl ID Genbank ID
KPC-1 Klebsiella pneumoniae Q9F663

2OV5 3E2K

3E2L 3RXW

3RXX

Carbapenems Penicillins Cephalosporins Monobactams AF297554 AF297554.1
Klebsiella pneumoniae M5SGU8 NA Carbapenems ANGI02000157 ANGI02000157.1
Klebsiella pneumoniae U7BVQ7 NA Carbapenems AXLI01000004 AXLI01000004.1
Klebsiella pneumoniae U7A522 NA Carbapenems AXLE01000003 AXLE01000003.1
Klebsiella pneumoniae U7ALW4 NA Carbapenems AXLF01000003 AXLF01000003.1
Klebsiella pneumoniae U7AG59 NA Carbapenems AXLF01000003 AXLF01000003.1
Klebsiella pneumoniae U7AJC0 NA Carbapenems AXLF01000003 AXLF01000003.1
Enterobacter Sp. U7CHK4 NA Carbapenems AXLK01000004 AXLK01000004.1
Klebsiella pneumoniae U7B550 NA Carbapenems AXLG01000004 AXLG01000004.1
Klebsiella pneumoniae U7BYA0 NA Carbapenems AXLJ01000004 AXLJ01000004.1
Escherichia coli U7BZN6 NA Carbapenems AXLH01000002 AXLH01000002.1
Mycobacterium abscessus I6YHT9 NA Carbapenems CP003699 CP003699.1
KPC-2 Klebsiella oxytoca Q848S6 NA Carbapenems Penicillins Cephalosporins Aztreonam AY210886 AY210886.1
Klebsiella pneumoniae Q93LQ9 NA Carbapenems JX430448 JX430448.1
Escherichia coli A8DS27 3C5A 3DW0 Carbapenems JQ867396 JQ867396.1
Citrobacter freundii A0N0D2 NA Carbapenems EF062508 EF062508.1
Enterobacter sp. K4P7Q9 NA NA JX500680 JX500680.1
Enterobacter Cloacae A8DS31 NA Carbapenems JN048640 JN048640.1
Klebsiella oxytoca F8SM50 NA Carbapenems HQ651092 HQ651092.1
Pseudomonas aeruginosa G8HAR0 NA NA JN545009 JN545009.1
Enterobacter aerogenes G3F1P4 NA Carbapenems JF434018 JF434018.1
Pseudomonas aeruginosa B0YZK5 NA Carbapenems EU176013 EU176013.1
Klebsiella pneumoniae R9BGM5 NA Carbapenems AQQA01000132 AQQA01000132.1
Klebsiella pneumoniae G8XCA1 NA Carbapenems CP003224 CP003224.1
Klebsiella pneumoniae S2GKE7 NA Carbapenems ARVM01000006 ARVM01000006.1
Klebsiella pneumoniae S2GL97 NA Carbapenems ARVP01000148 ARVP01000148.1
Klebsiella pneumoniae S2E2S7 NA Carbapenems ALWO02000023 ALWO02000023.1
Klebsiella pneumoniae S7IH87 NA Carbapenems ARSQ01000087 ARSQ01000087.1
Klebsiella pneumoniae S7FF43 NA Carbapenems ARSN01000117 ARSN01000117.1
Klebsiella pneumoniae S6ZZC4 NA Carbapenems ARSA01000063 ARSA01000063.1
Klebsiella pneumoniae S7HI25 NA Carbapenems ARSP01000198 ARSP01000198.1
Klebsiella pneumoniae S6ZM94 NA Carbapenems ARRZ01000061 ARRZ01000061.1
Klebsiella pneumoniae S7BQA3 NA Carbapenems ARSD01000003 ARSD01000003.1
Klebsiella pneumoniae S7G1V2 NA Carbapenems ARSO01000220 ARSO01000220.1
Klebsiella pneumoniae S7BS83 NA Carbapenems ARSF01000138 ARSF01000138.1
Klebsiella pneumoniae S7DI10 NA Carbapenems ARSI01000101 ARSI01000101.1
Klebsiella pneumoniae S7DXL0 NA Carbapenems ARSJ01000057 ARSJ01000057.1
Klebsiella pneumoniae S7C8T5 NA Carbapenems ARSC01000075 ARSC01000075.1
Klebsiella pneumoniae S6XMH3 NA Carbapenems ARRV01000080 ARRV01000080
Klebsiella pneumoniae S6XMH3 NA Carbapenems ARRV01000080 ARRV01000080.1
Klebsiella pneumoniae S6XB01 NA Carbapenems ARRU01000101 ARRU01000101.1
Klebsiella pneumoniae G3F1P4 NA Carbapenems KJ210592 KJ210592.1
Klebsiella pneumoniae N9UE70 NA Carbapenems AMWO01000440 AMWO01000440.1
Klebsiella pneumoniae M7QP12 NA Carbapenems AOGQ01000049 AOGQ01000049.1
Klebsiella pneumoniae S7ZK32 NA Carbapenems ATEZ01000138 ATEZ01000138.1
Klebsiella pneumoniae S8A395 NA Carbapenems ATAK01000080 ATAK01000080.1
KPC-3 Klebsiella pneumoniae Q93DC4 NA Carbapenems JN255861 JN255861.1
Klebsiella pneumoniae J2TA44 NA Carbapenems AKAI01000041 AKAI01000041.1
Escherichia coli A7WP95 NA Carbapenems AM774409 AM774409.1
Klebsiella pneumoniae J1TQ14 NA Carbapenems AJZV01000038 AJZV01000038.1
Klebsiella pneumoniae J2GXG7 NA Carbapenems AKAG01000041 AKAG01000041.1
Klebsiella pneumoniae J2IGL6 NA Carbapenems AKAJ01000049 AKAJ01000049.1
Klebsiella pneumoniae J2FKI1 NA Carbapenems AKAE01000044 AKAE01000044.1
Klebsiella pneumoniae J2N1N2 NA Carbapenems AJZY01000047 AJZY01000047.1
Klebsiella pneumoniae J2PHE6 NA Carbapenems AKAB01000033 AKAB01000033.1
Klebsiella pneumoniae J2G9V7 NA Carbapenems AKAF01000043 AKAF01000043.1
Klebsiella pneumoniae J2PPF6 NA Carbapenems AKAA01000039 AKAA01000039.1
Klebsiella pneumoniae J1UL34 NA Carbapenems AJZX01000055 AJZX01000055.1
Klebsiella pneumoniae J2Q8Q8 NACarbapenems AKAC01000039 AKAC01000039.1
Klebsiella pneumoniae J1YZF2 NA Carbapenems AKAH01000035 AKAH01000035.1
Klebsiella pneumoniae J2BPG7 NA Carbapenems AKAL01000053 AKAL01000053.1
Klebsiella pneumoniae J2TT42 NA Carbapenems AKAK01000039 AKAK01000039.1
Klebsiella pneumoniae J2NDY2 NA Carbapenems AJZZ01000040 AJZZ01000040.1
Klebsiella pneumoniae J2FHF9 NA Carbapenems AKAD01000042 AKAD01000042.1
Klebsiella pneumoniae J2LPP0 NA Carbapenems AJZW01000047 AJZW01000047.1
Klebsiella pneumoniae J2BP68 NA Carbapenems AKAM01000051 397441641
Klebsiella pneumoniae S2IJ69 NA Carbapenems ARPP01000157 510352960
Klebsiella pneumoniae S2H154 NA Carbapenems ARPO01000139 510343083
Klebsiella pneumoniae S1TLI7 NA Carbapenems AQQD01000200 509565239
Klebsiella pneumoniae S2ID45 NA Carbapenems ARPQ01000161 510358669
Klebsiella pneumoniae S2GJ31 NA Carbapenems ARVO01000056 ARVO01000056.1
Klebsiella pneumoniae S7ABL2 NA Carbapenems ARRY01000105 ARRY01000105.1
Klebsiella pneumoniae S7EXG3 NA Carbapenems ARSL01000030 ARSL01000030.1
Klebsiella pneumoniae S7CUQ8 NA Carbapenems ARSH01000109 ARSH01000109.1
Klebsiella pneumoniae S7CEB2 NA Carbapenems ARSG01000179 ARSG01000179.1
Klebsiella pneumoniae S7G256 NA Carbapenems ARSK01000149 ARSK01000149.1
Klebsiella pneumoniae S7DWJ1 NA Carbapenems ARSE01000005 ARSE01000005.1
Klebsiella pneumoniae S7ACB2 NA Carbapenems ARRX01000031 ARRX01000031.1
Klebsiella pneumoniae K4NUK1 NA Carbapenems JX524191 JX524191.1
Klebsiella pneumoniae S6Y2C4 NA Carbapenems ARRW01000156 ARRW01000156.1
KPC-4 Klebsiella pneumoniae B1PL86 NA Carbapenems JX193301 JX193301.1
Enterobacter cancerogenus B8Y3Y9 NA NA FJ4573382 FJ4573382.1
Enterobacter Cloacae I6SJK2 NA NA JQ837276 JQ837276.1
KPC-5 Pseudomonas aeruginosa B0ZSP4 NA NA EU400222 EU400222.1
Klebsiella pneumoniae L0APR4 NA NA JX193302 JX193302.1
KPC-6 Klebsiella pneumoniae B2CYF2 NA NA EU555534 EU555534.1
KPC-7 Klebsiella pneumoniae B3GS81 NA Carbapenems EU729727 EU729727.1
KPC-8 Klebsiella pneumoniae B6V684 NA NA FJ234412 FJ234412.1
KPC-9 Escherichia coli C0KTA5 NA NA FJ624872 FJ624872.1
KPC-10 Acinetobacter Baumanni C6JUP9 NA NA GQ140348 GQ140348.1
KPC-11 Klebsiella pneumoniae D7R1C6 NA NA HM021968 HM021968.1
KPC-12 Escherichia coli F2XNH2 NA NA HQ641422 HQ641422.1
Klebsiella pneumoniae E3VVM7 NA Carbapenems HQ258934 HQ258934.1
KPC-13 Enterobacter Cloacae F2X6V8 NA Carbapenems HQ342889 HQ342889.1
KPC-14 Klebsiella pneumoniae Q7BGE9 NA Cefotaxime GU211011 GU211011.1
Klebsiella pneumoniae K4NUK1 NA Carbapenems JX524191 JX524191.1
KPC-15 Klebsiella pneumoniae M1NGU8 NA Carbapenems KC433553 KC433553.1
KPC-16 Klebsiella pneumoniae M9T8M5 NA Carbapenems KC465199 KC465199.1
KPC-17 Klebsiella pneumoniae M9T6C6 NA Carbapenems KC465200 KC465200.1
References
  • Yigit H, Queenan AM, Rasheed JK, Biddle JW, Domenech-Sanchez A, Alberti S,Bush K, Tenover FC. Carbapenem-resistant strain of Klebsiella oxytoca harboring carbapenem-hydrolyzing beta-lactamase KPC-2. Antimicrob Agents Chemother. 2003 Dec;47(12):3881-9.PubMed PMID: 14638498
  • Smith Moland E, Hanson ND, Herrera VL, Black JA, Lockhart TJ, Hossain A, Johnson JA, Goering RV, Thomson KS. Plasmid-mediated, carbapenem-hydrolysing beta-lactamase, KPC-2, in Klebsiella pneumoniae isolates. J Antimicrob Chemother. 2003 Mar;51(3):711-4.PubMed PMID: 12615876
  • Naas T, Nordmann P, Vedel G, Poyart C. Plasmid-mediated carbapenem-hydrolyzing beta-lactamase KPC in a Klebsiella pneumoniae isolate from France. Antimicrob Agents Chemother. 2005 Oct;49(10):4423-4.PubMed PMID: 16189140
  • Villegas MV, Lolans K, Correa A, Suarez CJ, Lopez JA, Vallejo M, Quinn JP;Colombian Nosocomial Resistance Study Group. First detection of the plasmid-mediated class A carbapenemase KPC-2 in clinical isolates of Klebsiella pneumoniae from South America. Antimicrob Agents Chemother. 2006 Aug;50(8):2880-2.PubMed PMID: 16870793
  • Wei ZQ, Du XX, Yu YS, Shen P, Chen YG, Li LJ. Plasmid-mediated KPC-2 in a Klebsiella pneumoniae isolate from China. Antimicrob Agents Chemother. 2007 Feb;51(2):763-5. Epub 2006 Dec 4.PubMed PMID: 17145797
  • Monteiro J, Santos AF, Asensi MD, Peirano G, Gales AC. First report of KPC-2-producing Klebsiella pneumoniae strains in Brazil. Antimicrob Agents Chemother. 2009 Jan;53(1):333-4. doi: 10.1128/AAC.00736-08. Epub 2008 Nov 17.PubMed PMID: 19015350
  • Chen YT, Lin JC, Fung CP, Lu PL, Chuang YC, Wu TL, Siu LK. KPC-2-encoding plasmids from Escherichia coli and Klebsiella pneumoniae in Taiwan. J Antimicrob Chemother. 2014 Mar;69(3):628-31. doi: 10.1093/jac/dkt409. Epub 2013 Oct 11.PubMed PMID: 24123430
  • Roth AL, Lister PD, Hanson ND. Effect of drug treatment options on the mobility and expression of blaKPC. J Antimicrob Chemother. 2013 Dec;68(12):2779-85. doi: 10.1093/jac/dkt280. Epub 2013 Jul 16.PubMed PMID:23861308
  • Zhu JM, Jiang RJ, Mi ZH, Kong HS, Zhang F. Novel KPC variant from a carbapenem-resistant strain of Klebsiella pneumoniae in a Chinese hospital. Infect Control Hosp Epidemiol. 2011 Oct;32(10):1050-2. doi: 10.1086/662021.PubMed PMID: 21931263
  • Gomez SA, Pasteran FG, Faccone D, Tijet N, Rapoport M, Lucero C, Lastovetska O, Albornoz E, Galas M; KPC Group, Melano RG, Corso A, Petroni A. Clonal dissemination of Klebsiella pneumoniae ST258 harbouring KPC-2 in Argentina. Clin Microbiol Infect. 2011 Oct;17(10):1520-4. doi: 10.1111/j.1469-0691.2011.03600.x. Epub 2011 Aug 18.PubMed PMID: 21851480
  • Woodford N, Tierno PM Jr, Young K, Tysall L, Palepou MF, Ward E, Painter RE, Suber DF, Shungu D, Silver LL, Inglima K, Kornblum J, Livermore DM. Outbreak of Klebsiella pneumoniae producing a new carbapenem-hydrolyzing class A beta-lactamase, KPC-3, in a New York Medical Center. Antimicrob Agents Chemother. 2004 Dec;48(12):4793-9.PubMed PMID: 15561858
  • Chen L, Chavda KD, Fraimow HS, Mediavilla JR, Melano RG, Jacobs MR, Bonomo RA,Kreiswirth BN. Complete nucleotide sequences of blaKPC-4- and bla KPC-5-harboring IncN and IncX plasmids from Klebsiella pneumoniae strains isolated in New Jersey. Antimicrob Agents Chemother. 2013 Jan;57(1):269-76. doi: 10.1128/AAC.01648-12. Epub 2012 Oct 31.PubMed PMID: 23114770
  • Wolter DJ, Kurpiel PM, Woodford N, Palepou MF, Goering RV, Hanson ND. Phenotypic and enzymatic comparative analysis of the novel KPC variant KPC-5 and its evolutionary variants, KPC-2 and KPC-4. Antimicrob Agents Chemother. 2009 Feb;53(2):557-62. doi: 10.1128/AAC.00734-08. Epub 2008 Nov 17.PubMed PMID: 19015357
  • Robledo IE, Aquino EE, Santé MI, Santana JL, Otero DM, León CF, Vázquez GJ. Detection of KPC in Acinetobacter spp. in Puerto Rico. Antimicrob Agents Chemother. 2010 Mar;54(3):1354-7. doi: 10.1128/AAC.00899-09. Epub 2009 Dec 28.PubMed PMID: 20038618
  • Lamoureaux TL, Frase H, Antunes NT, Vakulenko SB. Antibiotic resistance and substrate profiles of the class A carbapenemase KPC-6. Antimicrob Agents Chemother. 2012 Nov;56(11):6006-8. doi: 10.1128/AAC.01338-12. Epub 2012 Aug 20PubMed PMID:22908150
  • Hidalgo-Grass C, Warburg G, Temper V, Benenson S, Moses AE, Block C,Strahilevitz J. KPC-9, a novel carbapenemase from clinical specimens in Israel.Antimicrob Agents Chemother. 2012 Nov;56(11):6057-9. doi: 10.1128/AAC.01156-12.Epub 2012 Sep 10.PubMed PMID: 22964247
  • Lascols C, Hackel M, Hujer AM, Marshall SH, Bouchillon SK, Hoban DJ, Hawser SP, Badal RE, Bonomo RA. Using nucleic acid microarrays to perform molecular epidemiology and detect novel ?-lactamases: a snapshot of extended-spectrum ?-lactamases throughout the world. J Clin Microbiol. 2012 May;50(5):1632-9. doi: 10.1128/JCM.06115-11. Epub 2012 Feb 8.PubMed PMID:22322349