Family: LEN
Class: A
Number of Variants: 7
Number of Proteins: 16
Number of Structures: 0
Taxonomic Lineage: Bacteria > Proteobacteria > Gammaproteobacteria > Enterobacteriales > Enterobacteriaceae > Klebsiella

  Alignment     Variability Plot     Phylogenetic Tree     Mutational Profile     Fingerprint     Sequences  

Variants Organism Uniprot ID PDB ID Hydrolytic profile Embl ID Genbank ID
LEN-1 Klebsiella pneumoniae Q5XPR7 NA NA AY743416 AY743416.1
Klebsiella pneumoniae P05192 NA NA X04515 X04515.1
Klebsiella pneumoniae Q939H3 NA NA AY037780 AY037780.1
Klebsiella pneumoniae B5D618 NA NA AM850914 AM850914.2
Klebsiella pneumoniae B5D615 NA NA AM850911 AM850911.2
Klebsiella pneumoniae B5D616 NA NA AM850912 AM850912.2
Klebsiella pneumoniae B5D617 NA NA AM850913 AM850913.2
Klebsiella pneumoniae B5D612 NA NA AM850908 AM850908.2
Klebsiella pneumoniae B5D613 NA NA AM850909 AM850909.2
Klebsiella pneumoniae B5D614 NA NA AM850910 AM850910.2
LEN-3 Klebsiella pneumoniae Q84H48 NA NA AY130286 AY130286.1
LEN-4 Klebsiella pneumoniae Q84H47 NA NA AY130287 AY130287.1
LEN-5 Klebsiella pneumoniae Q64HI6 NA NA AY633109 AAU25807.1
LEN-26 Escherichia coli H2ETE8 NA NA JQ067123 JQ067123.1
LEN-25 Klebsiella pneumoniae E9NST5 NA NA HQ709169 HQ709169.1
LEN-17 Staphylococcusepidermis A7X7N0 NA NA EF205593 EF205593.1
References
  • Arakawa Y, Ohta M, Kido N, Fujii Y, Komatsu T, Kato N. Close evolutionary relationship between the chromosomally encoded beta-lactamase gene of Klebsiella pneumoniae and the TEM beta-lactamase gene mediated by R plasmids. FEBS Lett.1986 Oct 20;207(1):69-74.PubMed PMID: 3533626
  • Jiang HX, Tang D, Liu YH, Zhang XH, Zeng ZL, Xu L, Hawkey PM. Prevalence and characteristics of β-lactamase and plasmid-mediated quinolone resistance genes in Escherichia coli isolated from farmed fish in China. J Antimicrob Chemother. 2012 Oct;67(10):2350-3. doi: 10.1093/jac/dks250. Epub 2012 Jul 18. PubMed PMID:22809702
  • Siebor E, Péchinot A, Duez JM, Neuwirth C. One new LEN enzyme and two new OKP enzymes in Klebsiella pneumoniae clinical isolates and proposed nomenclature for chromosomal beta-lactamases of this species. Antimicrob Agents Chemother. 2005Jul;49(7):3097-8.PubMed PMID: 15980410
  • Chaves J, Ladona MG, Segura C, Coira A, Reig R, Ampurdanés C. SHV-1beta-lactamase is mainly a chromosomally encoded species-specific enzyme in Klebsiella pneumoniae. Antimicrob Agents Chemother. 2001 Oct;45(10):2856-61.PubMed PMID: 11557480