Family: PEN
Class: A
Number of Variants: 5
Number of Proteins: 18
Number of Structures: 19
Taxonomic Lineage: Bacteria > Firmicutes > Bacilli > Bacillales > Bacillaceae > Bacillus
  Alignment     Variability Plot     Phylogenetic Tree     Mutational Profile     Fingerprint     Sequences  
Variants Organism Uniprot ID PDB ID Hydrolytic profile Embl ID Genbank ID
PENA Burkholderia pseudomallei Q79SS5 NA Ceftazidime, Clavulanic acid AY032868 AY032868.1
Burkholderia pseudomallei H9CTS3 NA Ceftazidime JQ364929 379134692
PENA Burkholderia mallei H9CTS7 NA Ceftazidime JQ364934 379134706
Burkholderia mallei H9CTS4 NA Ceftazidime JQ364931 379134698
Burkholderia cepacia O08350 NA NA U85041 2062565
Burkholderia mallei H7C785 3W4O 3W4P NA BX571966 499141818
Burkholderia pseudomallei Q934l2 NA Ceftazidime,Clavulanic acid AJ289103 16605597
Burkholderia pseudomallei Q934I1 NA NA AY032873 14578579
Burkholderia mallei C3TTN7 NA Ceftazidime,Amoxicillin FJ147203 223469166
Burkholderia pseudomallei1026b I1WSP5 NA NA CP002834 386864739
Collimonas fungivorans(strain Ter331) G0AJJ5 NA NA CP002745 340786568
Burkholderia pseudomallei354e I2M1H0 NA NA AHJD01000207 418555728
Burkholderia pseudomallei1258b l2KVT6 NA NA AHXA01000010 430952610
Burkhoderia cepacia (strain J2315) B4EFW2 N NA AM747721 98040042
PENP Bacillus licheniformis P00808

1I2S 1I2W 1MBL 1W7F 2BLM 2WK0 2Y91 3B3X 3LY3 3LY4 3M2J 3M2K 4BLM 3SH8 3SH9 3SOI

3SH7

NA V00093 45101017
PENB2 Burkhoderia cenopacia C1J897 NA NA FJ386399 225907432
PENB3 Burkhoderia cenopacia C1J899 NA NA FJ386401 225907436
PEN-E Burkholderia vietmiensis C1J898 NA NA FJ386400 225907434
References
  • Neugebauer K, Sprengel R, Schaller H. Penicillinase from Bacillus licheniformis: nucleotide sequence of the gene and implications for the biosynthesis of a secretory protein in a Gram-positive bacterium. Nucleic AcidsRes. 1981 Jun 11;9(11):2577-88.PubMed PMID: 6269055
  • Kroyer J, Chang S. The promoter-proximal region of the Bacillus licheniformis penicillinase gene: Nucleotide sequence and predicted leader peptide sequence.Gene. 1981 Dec;15(4):343-7. PubMed PMID: 6977472
  • Sarovich DS, Price EP, Von Schulze AT, Cook JM, Mayo M, Watson LM, RichardsonL, Seymour ML, Tuanyok A, Engelthaler DM, Pearson T, Peacock SJ, Currie BJ, KeimP, Wagner DM. Characterization of ceftazidime resistance mechanisms in clinical isolates of Burkholderia pseudomallei from Australia. PLoS One. 2012;7(2):e30789.doi: 10.1371/journal.pone.0030789. Epub 2012 Feb 21. PubMed PMID: 22363490
  • Tribuddharat C, Moore RA, Baker P, Woods DE. Burkholderia pseudomallei class a beta-lactamase mutations that confer selective resistance against ceftazidime or clavulanic acid inhibition. Antimicrob Agents Chemother. 2003 Jul;47(7):2082-7.PubMed PMID: 12821450
  • Poirel L, Rodriguez-Martinez JM, Plésiat P, Nordmann P. Naturally occurringClass A ss-lactamases from the Burkholderia cepacia complex. Antimicrob AgentsChemother. 2009 Mar;53(3):876-82. doi: 10.1128/AAC.00946-08. Epub 2008 Dec 15.PubMed PMID: 19075063
  • Trépanier S, Prince A, Huletsky A. Characterization of the penA and penR genes of Burkholderia cepacia 249 which encode the chromosomal class A penicillinase and its LysR-type transcriptional regulator. Antimicrob Agents Chemother. 1997 Nov;41(11):2399-405.PubMed PMID: 9371340
  • Sam IC, See KH, Puthucheary SD. Variations in ceftazidime and amoxicillin-clavulanate susceptibilities within a clonal infection of Burkholderia pseudomallei. J Clin Microbiol. 2009 May;47(5):1556-8. doi: 10.1128/JCM.01657-08. Epub 2009 Mar 18. PubMed PMID: 19297597