Family: PER
Class: A
Number of Variants: 8
Number of Proteins: 38
Number of Structures: 1
Taxonomic Lineage: Bacteria > Proteobacteria > Gammaproteobacteria

  Alignment     Variability Plot     Phylogenetic Tree     Mutational Profile     Fingerprint     Sequences  

Variants Organism Uniprot ID PDB ID Hydrolytic profile Embl ID Genbank ID
PER-1 Pseudomonas aeruginosa P37321 1E25 NA Z21957 Z21957.1
Pseudomonas aeruginosa Q6KCK7 NA NA FR847979 FR847979.1
Acinetobacter baumannii B5B4Y5 NA NA EU921231 EU921231.1
Acinetobacter baumannii B5B4Y8 NA NA EU921234 EU921234.1
chryseobacterium gleum D7W8K9 NA NA ACKQ02000007 ACKQ02000007.1
Bhargavaea cecembensis M7NHI5 NA NA AOFT01000005 AOFT01000005.1
Alcaligenes faecalis Q4A4J6 NA NA AJ627643 AJ627643.4
Aeromonas punctata D7P3C9 NA NA GQ891757 GQ891757.1
Acinetobacter baumannii A5HKJ8 NA Ceftazidime GU944725 GU944725.1
Acinetobacter baumannii Q19RL9 NA Carbapenems DQ489438 DQ489438.1
Salmonella infantis M4PVY9 NA Carbapenems KC707565 KC707565.1
Acinetobacter baumannii Q2LA82 NA Carbapenems DQ341275 DQ341275.1
Acinetobacter baumannii Q19RM0 NA Carbapenems DQ489437 DQ489437.1
Acinetobacter baumannii Q19RM1 NA Carbapenems DQ489436 DQ489436.1
Acinetobacter baumannii E5KCK4 NA Carbapenems HQ018643 HQ018643.1
Acinetobacter baumannii A7U8M8 NA Carbapenems EU022369 EU022369.1
Acinetobacter baumannii E8P8S8 NA Carbapenems CP001921 CP001921.1
Acinetobacter baumannii V9XYZ7 NA NA KF723588 KF723588.1
Acinetobacter baumannii V9XVD7 NA NA KF723590 KF723590.1
Acinetobacter baumannii V9XZ70 NA NA KF723589 KF723589.1
Acinetobacter baumannii V9XY88 NA NA KF723589 KF723589.1
Acinetobacter baumannii B5B4Y6 NA NA EU921232 EU921232.1
Acinetobacter baumannii B5B4Y7 NA NA EU921233 EU921233.1
Fibrella aestuarina BUZ I0KGH9 NA NA HE796683 HE796683.1
Pseudomonas aeruginosa Q58GF5 NA Carbapenems AY953376 AY953376.1
PER-2 Citrobacter freundii A2RP81 NA NA AM409516 AM409516.1
Salmonella typhimurium P74842 NA NA X93314 X93314.1
Escherichia coli Q5W2A0 NA NA AJ786366 AJ786366.1
PER-3 Aeromonas punctata Q5XQD3 NA NA AY740681 AY740681.1
Acinetobacter baumannii L7PBI5 NA NA JX128136 JX128136.1
PER-4 Proteus vulgaris B3VI32 NA NA EU748544 EU748544.1
PER-5 Providencia rettgeri C0KTK2 NA NA FJ627180 FJ627180.1
PER-5 Acinetobacter baumannii B2ZTR1 NA Carbapenems EU687473 EU687473.1
PER-6 Aeromonas allosaccharophila D5HSX5 NA NA HM453327 HM453327.1
Aeromonas veronii E9L0D5 NA NA HM453326 HM453326.1
Aeromonas media E2D6Z3 NA NA GQ885148 GQ885148.1
PER-7 Acinetobacter baumannii F8T7L4 NA Cephalosporins,Ceftazidime JQ639792 JQ639792.1
PER-8 Pseudomonas aeruginosa H6WJJ4 NA Cephalosporins,Ceftazidime JQ247994 JQ247994.1
References
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  • Wang H, Guo P, Sun H, Wang H, Yang Q, Chen M, Xu Y, Zhu Y. Molecularepidemiology of clinical isolates of carbapenem-resistant Acinetobacter spp. fromChinese hospitals. Antimicrob Agents Chemother. 2007 Nov;51(11):4022-8. Epub 2007Sep 10.PubMed PMID: 17846127
  • Opazo A, Sonnevend A, Lopes B, Hamouda A, Ghazawi A, Pal T, Amyes SG.Plasmid-encoded PER-7 β-lactamase responsible for ceftazidime resistance inAcinetobacter baumannii isolated in the United Arab Emirates. J AntimicrobChemother. 2012 Jul;67(7):1619-22. doi: 10.1093/jac/dks087. Epub 2012 Mar 14.PubMed PMID: 22419799
  • Girlich D, Poirel L, Nordmann P. PER-6, an extended-spectrum beta-lactamasefrom Aeromonas allosaccharophila. Antimicrob Agents Chemother. 2010Apr;54(4):1619-22. doi: 10.1128/AAC.01585-09. Epub 2010 Feb 9.PubMed PMID:20145085
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  • Power P, Di Conza J, Rodríguez MM, Ghiglione B, Ayala JA, Casellas JM, RadiceM, Gutkind G. Biochemical characterization of PER-2 and genetic environment of blaPER-2. Antimicrob Agents Chemother. 2007 Jul;51(7):2359-65. Epub 2007 Apr 16.PubMed PMID: 17438050
  • Mantengoli E, Rossolini GM. Tn5393d, a complex Tn5393 derivative carrying the PER-1 extended-spectrum beta-lactamase gene and other resistance determinants.Antimicrob Agents Chemother. 2005 Aug;49(8):3289-96. PubMed PMID: 16048938
  • Bauernfeind A, Stemplinger I, Jungwirth R, Mangold P, Amann S, Akalin E, AnğO, Bal C, Casellas JM. Characterization of beta-lactamase gene blaPER-2, whichencodes an extended-spectrum class A beta-lactamase. Antimicrob Agents Chemother.1996 Mar;40(3):616-20.PubMed PMID: 8851581
  • Bonnin RA, Potron A, Poirel L, Lecuyer H, Neri R, Nordmann P. PER-7, an extended-spectrum beta-lactamase with increased activity toward broad-spectrum cephalosporins in Acinetobacter baumannii. Antimicrob Agents Chemother. 2011 May;55(5):2424-7. doi: 10.1128/AAC.01795-10. Epub 2011 Mar 7.PubMed PMID: 21383087