Family: SME
Class: A
Number of Variants: 4
Number of Proteins: 5
Number of Structures: 1
Taxonomic Lineage: Bacteria > Proteobacteria > Gammaproteobacteria > Enterobacteriales > Enterobacteriaceae >

  Alignment     Variability Plot     Phylogenetic Tree     Mutational Profile     Fingerprint     Sequences  

Variants Organism Uniprot ID PDB ID Hydrolytic profile Embl ID Genbank ID
SME-1 Serratia marcescens P52682 NA Imipenem Z30237 Z30237.1
SME-2 Serratia marcescens Q9F7U6 NA Carbapenem KC352682 KC352682.1
Serratia marcescens Q54488 1DY6 Carbapenem KF481967 KF481967.1
SME-3 Serratia marcescens Q6PRG8 NA Carbapenem AY584237 AY584237.1
SME-5 Serratia marcescens X4Z2B6 NA Carbapenem KJ188748 KJ188748.1
References
  • Queenan AM, Torres-Viera C, Gold HS, Carmeli Y, Eliopoulos GM, Moellering RCJr, Quinn JP, Hindler J, Medeiros AA, Bush K. SME-type carbapenem-hydrolyzingclass A beta-lactamases from geographically diverse Serratia marcescens strains.Antimicrob Agents Chemother. 2000 Nov;44(11):3035-9.PubMed PMID: 11036019
  • Naas T, Vandel L, Sougakoff W, Livermore DM, Nordmann P. Cloning and sequenceanalysis of the gene for a carbapenem-hydrolyzing class A beta-lactamase, Sme-1,from Serratia marcescens S6. Antimicrob Agents Chemother. 1994 Jun;38(6):1262-70.PubMed PMID: 8092824
  • Sougakoff W, L'Hermite G, Pernot L, Naas T, Guillet V, Nordmann P, Jarlier V,Delettré J. Structure of the imipenem-hydrolyzing class A beta-lactamase SME-1from Serratia marcescens. Acta Crystallogr D Biol Crystallogr. 2002 Feb;58(Pt2):267-74. Epub 2002 Jan 24. PubMed PMID: 11807251
  • Fairfax MR, Queenan AM, Lephart PR, Kaye KS, Dror M, Arnous N, Salimnia TT,Mitchell RA, Alangaden G, Salimnia H. Detection of 2 SME-1carbapenemase-producing Serratia marcescens in Detroit. Diagn Microbiol InfectDis. 2011 Nov;71(3):325-6. doi: 10.1016/j.diagmicrobio.2011.06.007. Epub 2011 Aug 15. PubMed PMID: 21840669.
  • Queenan AM, Shang W, Schreckenberger P, Lolans K, Bush K, Quinn J. SME-3, a novel member of the Serratia marcescens SME family of carbapenem-hydrolyzing beta-lactamases. Antimicrob Agents Chemother. 2006 Oct;50(10):3485-7. PubMed PMID: 17005839
  • Naas T, Livermore DM, Nordmann P. Characterization of an LysR family protein, SmeR from Serratia marcescens S6, its effect on expression of the carbapenem-hydrolyzing beta-lactamase Sme-1, and comparison of this regulator with other beta-lactamase regulators. Antimicrob Agents Chemother. 1995 Mar;39(3):629-37. PubMed PMID: 7793864
  • Mataseje LF, Boyd DA, Delport J, Hoang L, Imperial M, Lefebvre B, Kuhn M, Van Caeseele P, Willey BM, Mulvey MR. Serratia marcescens harbouring SME-type class A carbapenemases in Canada and the presence of blaSME on a novel genomic island, SmarGI1-1. J Antimicrob Chemother. 2014 Jul;69(7):1825-9. doi: 10.1093/jac/dku040. Epub 2014 Mar 21.PubMed PMID: 24659751