Family: TOHO
Class: A
Number of Variants: 2
Number of Proteins: 4
Number of Structures: 17
Taxonomic Lineage: Bacteria > Proteobacteria > Gammaproteobacteria

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Variants Organism Uniprot ID PDB ID Hydrolytic profile Embl ID Genbank ID
TOHO-1 Escherichia coli Q47066 1BZA 1IYO 1IYP 1IYQ 1IYS 1WE4 2WYX 2XQZ2XR0 2ZQ7 2ZQ8 2ZQ92ZQA 4BD1 2ZQD 4BD0 2ZQC Cefotaxime D37830 D37830.1
Shigella flexneri Q4KXA5 NA NA AY671905 AY671905.1
Glaciecola arctica BSs20135 K6Z612 NA NA BAEO01000025 BAEO01000025.1
TOHO-2 Escherichia coli O69395 NA Penicillin G Carbenicillin Cephaloridine Cefoxitin Cefotaxime Ceftazidime Cephalothin Cephaloridine Cefotaxime Ceftizoxime D89862 D89862.1
References
  • Ishii Y, Ohno A, Taguchi H, Imajo S, Ishiguro M, Matsuzawa H. Cloning andsequence of the gene encoding a cefotaxime-hydrolyzing class A beta-lactamaseisolated from Escherichia coli. Antimicrob Agents Chemother. 1995Oct;39(10):2269-75.PubMed PMID: 8619581;
  • Ibuka A, Taguchi A, Ishiguro M, Fushinobu S, Ishii Y, Kamitori S, Okuyama K,Yamaguchi K, Konno M, Matsuzawa H. Crystal structure of the E166A mutant of extended-spectrum beta-lactamase Toho-1 at 1.8 A resolution. J Mol Biol. 1999 Feb5;285(5):2079-87.PubMed PMID: 9925786
  • Ma L, Ishii Y, Ishiguro M, Matsuzawa H, Yamaguchi K. Cloning and sequencing of the gene encoding Toho-2, a class A beta-lactamase preferentially inhibited by tazobactam. Antimicrob Agents Chemother. 1998 May;42(5):1181-6.PubMed PMID: 9593147
  • Andres P, Petroni A, Faccone D, Pasterán F, Melano R, Rapoport M, Martínez M,Culasso C, Di Bella A, Irigoyen B, Mulki J, Procopio A, von Specht M, Galas M.Extended-spectrum beta-lactamases in Shigella flexneri from Argentina: firstreport of TOHO-1 outside Japan. Int J Antimicrob Agents. 2005 Jun;25(6):501-7.PubMed PMID: 15878653