β-LacFamPred: HMM based prediction and annotation tool for β-lactamase families

β-Lactamase Families

On the basis of amino acid sequences Ambler classified β-Lactamases into four classes (A-D). Among four classes, Class B enzymes are known as metallo-β-lactamases, while enzymes of classes A, C & D are called as serine transferases. Each class is further divided into families on the basis of statistically significant similarities in amino acid sequences, as well as there characteristics like origin of name, hydrolyzing properties toward β-lactam antibiotics, geographical diversity. β-LacFamPred facilitated with ≥5 sequence families information, hyperlinked with their both (Protein/Nucleotide) MSAs, HMMs and sequences.

Ambler's classification

Class A
AST BEL BLAF BLAZ BPS BRO CARB CBLA CEPA CFXA CKO CME CTXM FAR FONA
GES HERA IBC IMI KLUA KLUC KPC LAP LEN LUT MAL NMC OKP ORN OXY
PENA PER PLA PSE RAHN ROB RTG SCO SFO SHV SME TEM TER TLA TOHO
VEB ARL AXC BCI CRH FRI L2 PAL PC1 PENB PLES SDA SGM XCC KLUY
 
Class C
ACC ACT AmpC CMY DHA FOX LAT MIR MOX SRT
ADC ESC PDC AQU CDA CMH LHK OCH SEC
 
Class D
OXA LCR
 
Class B
 
Sub-Class B1
Blab DIM GIM IMP IND NDM SIM TMB VIM CfiA
 
Sub-Class B2
CPHA
 
Sub-Class B3
GOB L1 LRA BJP


Statistics

Families: (New Release*)
Overall (96); class A (60); subclass B1 (10); subclass B2 (1); subclass B3 (4); class C (19); class D (2).

Families: (First Release)
Overall (95); class A (60); subclass B1 (10); subclass B2 (1); subclass B3 (3); class C (19); class D (2).

Last updated: Oct 12, 2022.

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